LILRB1

Across TCGA patient cohorts, LILRB1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LILRB1-associated genes across cancer lineages are PDK1_pS241, YAP_pS127, and IRS1. Each is linked with LILRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LILRB1-to-partner and partner-to-LILRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by LILRB1-low versus LILRB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRB1→partner) and Y-score (partner→LILRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDK1_pS241 →	-0.181	-2.309	.019	.033	3	2
LUAD	YAP_pS127 →	-0.333	-2.321	.031	.033	3	2
LUSC	IRS1 →	+0.136	+3.018	.005	.017	3	2
LUSC	PI3K-p85 →	-0.154	-3.450	.032	.005	3	2
UCEC	Di-Ras3 →	-0.136	-2.794	.006	.003	3	2
SKCM	TAZ →	+0.090	+1.427	.044	.026	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PDK1_pS241 by LILRB1 expression — LUAD

Explore this box plot interactively →