LILRA4

Across TCGA patient cohorts, LILRA4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LILRA4-associated genes across cancer lineages are Annexin-1, MYH11, and EGFR_pY1068. Each is linked with LILRA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LILRA4-to-partner and partner-to-LILRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by LILRA4-low versus LILRA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRA4→partner) and Y-score (partner→LILRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.540	+2.720	.006	.003	3	3
LUSC	MYH11 →	-1.096	-3.169	.009	.018	3	2
UCEC	EGFR_pY1068 →	-0.275	-2.662	.003	<.001	3	2
UCEC	Rab25 →	-0.317	-2.321	.010	.034	3	2
LUAD	Cyclin-E1 →	+0.285	+3.000	.044	.036	3	1
UCEC	A-Raf_pS299 →	-0.113	-2.584	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Annexin-1 by LILRA4 expression — UCEC

Explore this box plot interactively →