LILRA4

Across TCGA cell cohorts, LILRA4 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LILRA4-associated genes across cancer lineages are USP17L17, ZCCHC13, and PRG3. Each is linked with LILRA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LILRA4-to-partner and partner-to-LILRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L17 grouped by LILRA4-low versus LILRA4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRA4→partner) and Y-score (partner→LILRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L17 →	+0.006	+4.022	<.001	.006	3	2
STOMACH	ZCCHC13 →	+0.025	+4.285	<.001	.007	3	2
LUNG_SCLC	PRG3 →	+0.033	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	DEFB108B →	+0.107	+5.169	<.001	.001	3	1
CNS	OR52E6 →	+0.035	+5.754	<.001	.002	3	1
LARGE_INTESTINE	TMCO5A →	+0.027	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

USP17L17 by LILRA4 expression — SKIN

Explore this box plot interactively →