LILRA1

Across TCGA patient cohorts, LILRA1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LILRA1-associated genes across cancer lineages are Chk1, Cyclin-B1, and EGFR_pY1068. Each is linked with LILRA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LILRA1-to-partner and partner-to-LILRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by LILRA1-low versus LILRA1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LILRA1→partner) and Y-score (partner→LILRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Chk1 →	+0.204	+3.321	.030	.009	3	3
UCEC	Cyclin-B1 →	+0.745	+2.502	<.001	.002	3	3
LUAD	EGFR_pY1068 →	-0.455	-2.321	.022	.032	3	2
LUAD	MSH6 →	+0.369	+2.610	.002	.005	3	2
LUAD	Stathmin →	+0.141	+2.115	.048	.018	3	2
UCEC	EGFR →	-0.154	-2.321	.014	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Chk1 by LILRA1 expression — LUAD

Explore this box plot interactively →