LIG4

Across TCGA pan-cancer cohorts, LIG4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LIG4 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LIG4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LIG4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LSCC, and GBM are the cancer types where LIG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.982	0.504	.002	59	view →
LSCC	OS	Quartile	All	0.636	0.966	<.001	19	view →
GBM	OS	Tertile	All	0.251	0.579	.005	12	view →
HNSC	OS	Median	III,IV	0.945	1.000	.032	4	view →
LUAD	OS	Quartile	II,III,IV	0.356	0.788	.014	4	view →
PDAC	DFS	Quartile	II,III,IV	0.622	0.772	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LIG4–CCRCC (OS)

Open the CCRCC breakdown →