LIG4

Across TCGA patient cohorts, LIG4 RNA expression is significantly associated with the RNA expression of many other genes, with 20,129 significant associations in total. UVM shows the largest number of these associations.

The most reproducible LIG4-associated genes across cancer lineages are ZDHHC21, CMTR2, and SOCS4. Each is linked with LIG4 in more than 33 cancer types. Because this analysis shows association rather than direction, both LIG4-to-partner and partner-to-LIG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG4 versus ZDHHC21 in UVM, with a Pearson correlation of 0.96.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG4→partner) and Y-score (partner→LIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZDHHC21 →	+1.321	+1.812	<.001	<.001	3	34
UVM	CMTR2 →	+1.494	+1.687	<.001	<.001	3	34
UVM	SOCS4 →	+1.497	+1.871	<.001	<.001	3	34
UVM	ACBD3 →	+1.416	+1.571	<.001	<.001	3	34
UVM	MOSMO →	+1.346	+1.792	<.001	<.001	3	34
UVM	NHLRC3 →	+1.289	+1.710	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,129 associations by consensus.

LIG4 vs ZDHHC21 — UVM

Explore this scatter interactively →