LIG4

Across TCGA patient cohorts, LIG4 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,115 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible LIG4-associated proteins across cancer lineages are XRCC4, ARHGEF7, and TFAP4_S139. Each is linked with LIG4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LIG4-to-partner and partner-to-LIG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG4 versus XRCC4 in OV, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG4→partner) and Y-score (partner→LIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	XRCC4 →	+0.260	+0.526	.001	.002	3	5
GBM	ARHGEF7 →	+0.232	+0.320	<.001	<.001	3	5
HNSC	TFAP4_S139 →	-0.467	-0.373	.001	.003	3	4
LSCC	CUL4A →	+0.302	+0.342	<.001	<.001	3	4
PDAC	KPNA3 →	+0.414	+0.416	<.001	<.001	3	4
PDAC	DOCK9_S443 →	+0.354	+0.342	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,115 associations by consensus.

LIG4 vs XRCC4 — OV

Explore this scatter interactively →