LIG4

Across TCGA patient cohorts, LIG4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,054 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LIG4-associated genes across cancer lineages are RAVER2, ZNF599, and TM9SF2. Each is linked with LIG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both LIG4-to-partner and partner-to-LIG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG4 versus RAVER2 in GBM, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG4→partner) and Y-score (partner→LIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RAVER2 →	-0.731	-0.242	<.001	<.001	3	4
HNSC	ZNF599 →	-0.556	-0.187	.001	.006	3	4
BRCA	TM9SF2 →	+0.487	+0.290	.001	<.001	3	4
LSCC	LAMP1 →	+0.510	+0.158	<.001	<.001	3	4
OV	NAXD →	+0.580	+0.335	.002	.007	3	4
GBM	LHFPL2 →	+0.608	+0.268	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,054 associations by consensus.

LIG4 vs RAVER2 — GBM

Explore this scatter interactively →