LIG4

Across TCGA patient cohorts, LIG4 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIG4-associated genes across cancer lineages are Annexin-1, Cyclin-E2, and PKC-a_pS657. Each is linked with LIG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIG4-to-partner and partner-to-LIG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by LIG4-low versus LIG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG4→partner) and Y-score (partner→LIG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.459	+1.697	.007	.012	3	3
COAD	Cyclin-E2 →	+0.278	+3.025	.014	.018	3	3
COAD	PKC-a_pS657 →	-0.479	-3.000	.001	.035	3	2
COAD	PKC-a →	-0.466	-3.000	<.001	.035	3	2
UCEC	EGFR_pY1068 →	-0.286	-2.321	<.001	<.001	3	2
UCEC	eIF4E →	+0.155	+2.584	.023	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Annexin-1 by LIG4 expression — UCEC

Explore this box plot interactively →