LIG3

Across TCGA pan-cancer cohorts, LIG3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LIG3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LIG3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LIG3 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

HNSC, COAD, and LSCC are the cancer types where LIG3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.912	1.000	.033	16	view →
COAD	DFS	Quartile	All	1.000	0.811	.039	12	view →
LSCC	OS	Quartile	All	1.000	0.713	.011	8	view →
OV	DFS	Median	All	0.867	1.000	.035	4	view →
GBM	OS	Quartile	All	0.670	0.349	.024	4	view →
LUAD	OS	Tertile	III,IV	0.824	0.388	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LIG3–HNSC (DFS)

Open the HNSC breakdown →