LIG3

Across TCGA patient cohorts, LIG3 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,221 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIG3-associated proteins across cancer lineages are SRSF9, ACLY_S481, and CBX8. Each is linked with LIG3 in more than 6 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG3 versus SRSF9 in LSCC, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SRSF9 →	+0.439	+0.637	<.001	<.001	3	7
LSCC	ACLY_S481 →	+0.444	+0.720	<.001	<.001	3	7
GBM	CBX8 →	+0.573	+0.484	<.001	<.001	3	7
LSCC	XAB2 →	+0.366	+0.797	<.001	<.001	3	7
LSCC	XRCC1 →	+0.444	+0.952	<.001	<.001	3	7
GBM	ZNF207 →	+0.254	+0.359	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,221 associations by consensus.

LIG3 vs SRSF9 — LSCC

Explore this scatter interactively →