LIG3

Across TCGA patient cohorts, LIG3 protein abundance is significantly associated with the RNA expression of many other genes, with 20,659 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIG3-associated genes across cancer lineages are MRM1, ZNF830, and AATF. Each is linked with LIG3 in more than 9 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG3 versus MRM1 in LSCC, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRM1 →	+0.877	+0.567	<.001	<.001	3	10
LSCC	ZNF830 →	+0.684	+0.670	<.001	<.001	3	9
LSCC	AATF →	+0.744	+0.623	<.001	<.001	3	9
LSCC	MRPL45 →	+0.882	+0.646	<.001	<.001	3	9
LSCC	NLE1 →	+1.038	+0.684	<.001	<.001	3	9
HNSC	TMEM97 →	+1.308	+0.416	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,659 associations by consensus.

LIG3 vs MRM1 — LSCC

Explore this scatter interactively →