LIG3

Across TCGA patient cohorts, LIG3 mutation is significantly associated with the RNA expression of many other genes, with 2,966 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIG3-associated genes across cancer lineages are NDUFA6, FOXRED2, and OIP5. Each is linked with LIG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by LIG3-low versus LIG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.532	+1.818	<.001	<.001	3	3
UCEC	FOXRED2 →	+0.433	+2.711	.003	.003	3	3
UCEC	OIP5 →	+0.771	+1.828	<.001	<.001	3	3
UCEC	TLE6 →	+0.589	+1.399	.001	.005	3	3
UCEC	KNSTRN →	+0.494	+2.679	<.001	<.001	3	3
UCEC	KNL1 →	+0.540	+2.329	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,966 associations by consensus.

NDUFA6 by LIG3 expression — UCEC

Explore this box plot interactively →