LIG3

Across TCGA patient cohorts, LIG3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIG3-associated genes across cancer lineages are FoxM1, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with LIG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by LIG3-low versus LIG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.238	+2.432	.003	<.001	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.330	-1.847	.019	.007	3	3
STAD	PDCD4 →	-0.472	-3.000	.023	.034	3	2
COAD	eEF2 →	+0.422	+2.815	.009	.036	3	2
COAD	4E-BP1 →	+0.312	+2.815	.009	.036	3	2
UCEC	INPP4B →	-0.240	-2.415	.018	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FoxM1 by LIG3 expression — UCEC

Explore this box plot interactively →