LIG3

Across TCGA cell cohorts, LIG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,271 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LIG3-associated GO terms across cancer lineages are Double-strand break repair via alternative nonhomologous end joining, DNA strand elongation involved in DNA replication, and Base-excision repair, gap-filling. Each is linked with LIG3 in more than 18 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via alternative nonhomologous end joining grouped by LIG3-low versus LIG3-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Double-strand break repair via alternative nonhomologous end joining →	+0.147	+1.343	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.179	+1.172	<.001	<.001	3	17
BONE	Base-excision repair, gap-filling →	+0.150	+0.840	.001	.003	3	16
SOFT_TISSUE	Constitutive heterochromatin formation →	+0.096	+0.767	<.001	<.001	3	16
LARGE_INTESTINE	Microtubule nucleation →	+0.152	+1.032	<.001	<.001	3	16
SOFT_TISSUE	Regulation of transcription by RNA polymerase I →	+0.108	+0.889	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,271 associations by consensus.

Double-strand break repair via alternative nonhomologous end joining by LIG3 expression — PANCREAS

Explore this box plot interactively →