LIG3

Across TCGA cell cohorts, LIG3 mutation is significantly associated with the RNA expression of many other genes, with 559 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIG3-associated genes across cancer lineages are CRYBB3, CST2, and PROP1. Each is linked with LIG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIG3-to-partner and partner-to-LIG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB3 grouped by LIG3-low versus LIG3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG3→partner) and Y-score (partner→LIG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRYBB3 →	+0.086	+4.152	.001	.009	3	1
BLOOD_Leukemia	CST2 →	+0.499	+4.152	<.001	.009	3	1
BLOOD_Leukemia	PROP1 →	+0.021	+4.874	.007	.002	3	1
BREAST	MRAP →	+0.039	+4.672	.008	.002	3	1
UPPER_AERODIGESTIVE_TRACT	UTF1 →	+0.170	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	IQCF6 →	+0.052	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

CRYBB3 by LIG3 expression — BLOOD_Leukemia

Explore this box plot interactively →