LIG1

Across TCGA pan-cancer cohorts, LIG1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LIG1 data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in pheochromocytoma and paraganglioma (PCPG), where higher LIG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LIG1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

PCPG, UCEC, and BLCA are the cancer types where LIG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PCPG	OS	Median	All	0.142	0.963	<.001	12	view →
UCEC	OS	Median	IV	0.207	0.528	.035	6	view →
BLCA	DFS	Median	II,III,IV	1.000	0.327	.038	4	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LIG1–PCPG (OS)

Open the PCPG breakdown →