LIG1

Across TCGA patient cohorts, LIG1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,207 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LIG1-associated genes across cancer lineages are GINS1, MYBL2, and E2F1. Each is linked with LIG1 in more than 9 cancer types. Because this analysis shows association rather than direction, both LIG1-to-partner and partner-to-LIG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIG1 versus GINS1 in UCEC, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG1→partner) and Y-score (partner→LIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS1 →	+1.317	+0.616	<.001	<.001	3	10
BRCA	MYBL2 →	+2.113	+0.626	<.001	<.001	3	10
UCEC	E2F1 →	+1.242	+0.442	<.001	<.001	3	10
LUAD	CENPI →	+1.154	+0.432	<.001	<.001	3	10
UCEC	OIP5 →	+0.821	+0.381	<.001	<.001	3	10
OV	MCM4 →	+1.189	+0.558	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,207 associations by consensus.

LIG1 vs GINS1 — UCEC

Explore this scatter interactively →