LIG1

Across TCGA patient cohorts, LIG1 mutation is significantly associated with the RNA expression of many other genes, with 3,814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIG1-associated genes across cancer lineages are NUSAP1, RFC5, and KNSTRN. Each is linked with LIG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LIG1-to-partner and partner-to-LIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUSAP1 grouped by LIG1-low versus LIG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG1→partner) and Y-score (partner→LIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NUSAP1 →	+0.707	+3.584	.001	.002	3	5
SKCM	RFC5 →	+0.517	+3.491	.004	.002	3	4
SKCM	KNSTRN →	+0.610	+3.478	.007	.002	2	5
SKCM	MELK →	+0.830	+3.465	.004	.003	3	4
UCEC	SAAL1 →	+0.439	+1.942	<.001	.002	3	4
UCEC	CHAF1A →	+0.678	+2.072	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,814 associations by consensus.

NUSAP1 by LIG1 expression — COAD

Explore this box plot interactively →