LIG1

Across TCGA patient cohorts, LIG1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIG1-associated genes across cancer lineages are TFRC, HER3_pY1289, and 4E-BP1. Each is linked with LIG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LIG1-to-partner and partner-to-LIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by LIG1-low versus LIG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG1→partner) and Y-score (partner→LIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFRC →	+0.671	+3.195	.010	.010	3	4
UCEC	HER3_pY1289 →	+0.078	+1.441	.003	.006	3	3
UCEC	4E-BP1 →	+0.444	+4.169	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.569	+2.169	.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.196	-1.643	.011	.003	3	2
UCEC	eIF4E →	+0.204	+3.100	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

TFRC by LIG1 expression — COAD

Explore this box plot interactively →