LIG1

Across TCGA cell cohorts, LIG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,951 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LIG1-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, Double-strand break repair via break-induced replication, and Mitotic DNA replication. Each is linked with LIG1 in more than 19 cancer types. Because this analysis shows association rather than direction, both LIG1-to-partner and partner-to-LIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by LIG1-low versus LIG1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG1→partner) and Y-score (partner→LIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation involved in DNA replication →	+0.248	+1.976	<.001	<.001	3	20
BONE	Double-strand break repair via break-induced replication →	+0.249	+1.791	.005	.001	3	19
BONE	Mitotic DNA replication →	+0.232	+1.982	.001	<.001	3	18
BONE	Nuclear DNA replication →	+0.224	+2.060	<.001	<.001	3	18
OESOPHAGUS	DNA replication proofreading →	+0.190	+1.218	<.001	<.001	3	18
BONE	DNA strand elongation →	+0.203	+1.572	<.001	.003	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,951 associations by consensus.

DNA strand elongation involved in DNA replication by LIG1 expression — BONE

Explore this box plot interactively →