LIG1

Across TCGA cell cohorts, LIG1 mutation is significantly associated with the drug of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIG1-associated genes across cancer lineages are GSK690693, QL-XII-47, and Pevonedistat. Each is linked with LIG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LIG1-to-partner and partner-to-LIG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK690693 grouped by LIG1-low versus LIG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIG1→partner) and Y-score (partner→LIG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK690693 →	+0.859	+2.874	<.001	.021	3	2
LUNG_NSCLC_LUAD	QL-XII-47 →	+0.520	+2.856	.048	.025	3	2
LARGE_INTESTINE	Pevonedistat →	+0.696	+2.649	.044	.046	3	1
LARGE_INTESTINE	123829 →	+0.578	+2.871	.036	.021	3	1
LARGE_INTESTINE	OF-1 →	+0.280	+2.868	.041	.022	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.640	+2.868	.006	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

GSK690693 by LIG1 expression — LARGE_INTESTINE

Explore this box plot interactively →