LIFR

Across TCGA patient cohorts, LIFR protein abundance is significantly associated with the RNA expression of many other genes, with 5,589 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LIFR-associated genes across cancer lineages are BDH2, FAM189A2, and FAT3. Each is linked with LIFR in more than 2 cancer types. Because this analysis shows association rather than direction, both LIFR-to-partner and partner-to-LIFR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIFR versus BDH2 in CCRCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIFR→partner) and Y-score (partner→LIFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BDH2 →	+0.643	+0.457	.003	<.001	3	3
GBM	FAM189A2 →	+0.922	+0.437	<.001	<.001	3	3
GBM	FAT3 →	+1.084	+0.567	<.001	<.001	3	3
LUAD	RNU5E-8P →	+0.837	+0.278	.001	.003	3	3
LUAD	RNU6-1200P →	+0.773	+0.278	.007	.002	3	3
LUAD	MFF-DT →	+0.321	+0.216	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,589 associations by consensus.

LIFR vs BDH2 — CCRCC

Explore this scatter interactively →