LIFR

Across TCGA patient cohorts, LIFR mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIFR-associated genes across cancer lineages are STAT3_pY705, 4E-BP1, and ATM. Each is linked with LIFR in more than 4 cancer types. Because this analysis shows association rather than direction, both LIFR-to-partner and partner-to-LIFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by LIFR-low versus LIFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIFR→partner) and Y-score (partner→LIFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.350	-1.652	<.001	.004	3	5
UCEC	4E-BP1 →	+0.296	+2.662	<.001	<.001	3	4
UCEC	ATM →	-0.512	-1.447	<.001	.002	3	4
COAD	Chk1 →	+0.287	+2.008	.001	.018	3	3
SKCM	IRS1 →	+0.108	+1.125	.019	.030	3	3
UCEC	14-3-3_beta →	-0.082	-1.558	.003	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

STAT3_pY705 by LIFR expression — UCEC

Explore this box plot interactively →