LIFR

Across TCGA cell cohorts, LIFR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,686 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LIFR-associated GO terms across cancer lineages are Regulation of post-translational protein modification, Regulation of protein modification by small protein conjugation or removal, and Signal transduction in response to DNA damage. Each is linked with LIFR in more than 12 cancer types. Because this analysis shows association rather than direction, both LIFR-to-partner and partner-to-LIFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of post-translational protein modification grouped by LIFR-low versus LIFR-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LIFR→partner) and Y-score (partner→LIFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of post-translational protein modification →	+0.060	+1.260	<.001	<.001	2	13
KIDNEY	Regulation of protein modification by small protein conjugation or removal →	+0.058	+1.078	<.001	.001	3	11
BREAST	Signal transduction in response to DNA damage →	+0.055	+1.285	.001	.001	3	10
URINARY_TRACT	Intracellular transport of virus →	+0.116	+1.466	<.001	<.001	3	10
URINARY_TRACT	Transport of virus →	+0.116	+1.466	<.001	<.001	3	10
STOMACH	Collagen biosynthetic process →	+0.153	+3.057	.008	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,686 associations by consensus.

Regulation of post-translational protein modification by LIFR expression — KIDNEY

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