LIFR

Across TCGA cell cohorts, LIFR mutation is significantly associated with the RNA expression of many other genes, with 1,121 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LIFR-associated genes across cancer lineages are OR13C4, KRTAP10-7, and SLCO1C1. Each is linked with LIFR in more than 1 cancer types. Because this analysis shows association rather than direction, both LIFR-to-partner and partner-to-LIFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C4 grouped by LIFR-low versus LIFR-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIFR→partner) and Y-score (partner→LIFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR13C4 →	+0.035	+5.169	<.001	.005	3	2
LUNG_NSCLC_LUAD	KRTAP10-7 →	+0.009	+4.078	.001	.009	3	2
LARGE_INTESTINE	SLCO1C1 →	+0.261	+2.128	.002	.002	3	2
LARGE_INTESTINE	TBC1D3D →	+0.490	+2.743	.002	.001	3	2
BLOOD_Myeloma	SALL3 →	+0.060	+4.807	<.001	.006	3	1
BREAST	MT1B →	+0.113	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,121 associations by consensus.

OR13C4 by LIFR expression — BREAST

Explore this box plot interactively →