LIFR-AS1

Across TCGA pan-cancer cohorts, LIFR-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LIFR-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LIFR-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LIFR-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

LUAD, KIRC, and KIRP are the cancer types where LIFR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.746	0.541	<.001	107	view →
KIRC	OS	Median	All	0.699	0.566	<.001	98	view →
KIRP	OS	Tertile	All	0.830	0.621	<.001	96	view →
STAD	OS	Median	All	0.613	0.758	<.001	61	view →
UCS	OS	Tertile	II,III,IV	0.716	0.194	<.001	60	view →
PAAD	OS	Median	All	0.608	0.360	.001	56	view →
BRCA	OS	Tertile	III,IV	0.970	0.841	<.001	54	view →
SKCM	DFS	Quartile	All	0.689	0.551	.001	43	view →
LUSC	OS	Median	All	0.816	0.703	.002	20	view →
LGG	DFS	Quartile	All	0.683	0.410	.001	12	view →
PRAD	DFS	Tertile	All	0.934	0.846	.006	12	view →
UCEC	DFS	Tertile	All	0.518	0.662	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LIFR-AS1–LUAD (OS)

Open the LUAD breakdown →