LIAS

Across TCGA patient cohorts, LIAS protein abundance is significantly associated with the protein abundance of many other proteins, with 17,010 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LIAS-associated proteins across cancer lineages are GUF1, TFB1M, and MRPL49. Each is linked with LIAS in more than 6 cancer types. Because this analysis shows association rather than direction, both LIAS-to-partner and partner-to-LIAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LIAS versus GUF1 in UCEC, with a Pearson correlation of 0.56.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LIAS→partner) and Y-score (partner→LIAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUF1 →	+0.367	+0.323	<.001	<.001	3	7
CCRCC	TFB1M →	+0.322	+0.302	<.001	<.001	3	5
PDAC	MRPL49 →	+0.430	+0.491	<.001	.002	3	5
COAD	NSUN4 →	+0.618	+1.038	<.001	.002	1	7
LUAD	PRDX3 →	+0.377	+0.414	<.001	<.001	3	5
UCEC	ACOT13 →	+0.345	+0.263	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,010 associations by consensus.

LIAS vs GUF1 — UCEC

Explore this scatter interactively →