LIAS

Across TCGA patient cohorts, LIAS mutation is significantly associated with the RNA expression of many other genes, with 3,172 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIAS-associated genes across cancer lineages are LEO1, MTCYBP9, and SAR1A. Each is linked with LIAS in more than 2 cancer types. Because this analysis shows association rather than direction, both LIAS-to-partner and partner-to-LIAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LEO1 grouped by LIAS-low versus LIAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIAS→partner) and Y-score (partner→LIAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LEO1 →	+0.419	+4.032	.001	<.001	3	3
LUAD	MTCYBP9 →	+0.189	+5.087	<.001	.004	3	3
UCEC	SAR1A →	+0.338	+3.721	.002	<.001	3	3
UCEC	UBE2F →	+0.305	+1.857	<.001	<.001	3	3
UCEC	CDCA2 →	+0.668	+2.115	<.001	<.001	3	3
UCEC	KCTD9 →	+0.654	+4.021	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,172 associations by consensus.

LEO1 by LIAS expression — UCEC

Explore this box plot interactively →