LIAS

Across TCGA patient cohorts, LIAS mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LIAS-associated genes across cancer lineages are eEF2, MSH6, and Annexin-1. Each is linked with LIAS in more than 1 cancer types. Because this analysis shows association rather than direction, both LIAS-to-partner and partner-to-LIAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LIAS-low versus LIAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LIAS→partner) and Y-score (partner→LIAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.306	+1.321	.010	.029	3	2
UCEC	MSH6 →	-0.364	-2.584	<.001	.010	3	2
UCEC	Annexin-1 →	+0.576	+1.697	.001	.012	3	2
UCEC	TFRC →	+0.405	+1.321	.022	.029	3	2
UCEC	ATM →	-0.464	-1.584	.002	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.761	+2.019	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by LIAS expression — UCEC

Explore this box plot interactively →