LHX8

Across TCGA patient cohorts, LHX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,801 significant associations in total. STAD shows the largest number of these associations.

The most reproducible LHX8-associated GO terms across cancer lineages are Cellular response to radiation, Nuclear membrane organization, and Response to UV. Each is linked with LHX8 in more than 13 cancer types. Because this analysis shows association rather than direction, both LHX8-to-partner and partner-to-LHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to radiation grouped by LHX8-low versus LHX8-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX8→partner) and Y-score (partner→LHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cellular response to radiation →	+0.052	+0.093	<.001	<.001	3	13
STAD	Nuclear membrane organization →	+0.071	+0.109	<.001	<.001	3	13
STAD	Response to UV →	+0.094	+0.143	<.001	<.001	3	13
ESCA	Regulation of signal transduction by p53 class mediator →	+0.076	+0.329	.002	.005	1	14
STAD	Cellular senescence →	+0.091	+0.159	<.001	<.001	3	12
STAD	Regulation of DNA-templated transcription initiation →	+0.096	+0.147	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,801 associations by consensus.

Cellular response to radiation by LHX8 expression — STAD

Explore this box plot interactively →