LHX8

Across TCGA patient cohorts, LHX8 mutation is significantly associated with the RNA expression of many other genes, with 3,042 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX8-associated genes across cancer lineages are KSR1P1, EIF3JP1, and CMC2. Each is linked with LHX8 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX8-to-partner and partner-to-LHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR1P1 grouped by LHX8-low versus LHX8-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX8→partner) and Y-score (partner→LHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	KSR1P1 →	+0.195	+3.475	<.001	.008	3	3
UCEC	EIF3JP1 →	+0.138	+1.742	.001	.009	3	3
UCEC	CMC2 →	+0.443	+2.874	<.001	<.001	3	3
UCEC	ARL1 →	+0.395	+2.550	.003	<.001	3	3
SKCM	DXO →	+0.540	+3.484	<.001	.002	3	3
SKCM	C6orf136 →	+0.405	+3.347	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,042 associations by consensus.

KSR1P1 by LHX8 expression — CESC

Explore this box plot interactively →