LHX8

Across TCGA patient cohorts, LHX8 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX8-associated genes across cancer lineages are Di-Ras3, Caspase-7-cleavedD198, and mTOR_pS2448. Each is linked with LHX8 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX8-to-partner and partner-to-LHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by LHX8-low versus LHX8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX8→partner) and Y-score (partner→LHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.112	-3.308	.043	.009	3	3
LUAD	Caspase-7-cleavedD198 →	+0.623	+2.186	.004	.034	3	2
LUSC	mTOR_pS2448 →	-0.264	-2.972	.005	.036	3	2
UCEC	PDCD4 →	-0.454	-1.415	.010	.046	3	2
UCEC	VHL →	-0.726	-2.000	.004	.029	3	2
SKCM	GSK3-a-b →	+0.165	+3.584	.027	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Di-Ras3 by LHX8 expression — UCEC

Explore this box plot interactively →