LHX8

Across TCGA cell cohorts, LHX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 531 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LHX8-associated GO terms across cancer lineages are Regulation of dopamine receptor signaling pathway, CGMP biosynthetic process, and Action potential. Each is linked with LHX8 in more than 3 cancer types. Because this analysis shows association rather than direction, both LHX8-to-partner and partner-to-LHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of dopamine receptor signaling pathway grouped by LHX8-low versus LHX8-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX8→partner) and Y-score (partner→LHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of dopamine receptor signaling pathway →	-0.177	-1.159	<.001	<.001	3	4
BLOOD_Myeloma	CGMP biosynthetic process →	+1.258	+2.260	<.001	.001	3	3
SKIN	Action potential →	-0.046	-0.788	<.001	.003	3	3
LARGE_INTESTINE	Mitotic cytokinesis →	+0.058	+0.017	<.001	.007	3	3
KIDNEY	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.071	+0.567	.002	.003	2	4
KIDNEY	Positive regulation of transforming growth factor beta receptor signaling pathway →	+0.071	+0.567	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 531 associations by consensus.

Regulation of dopamine receptor signaling pathway by LHX8 expression — SKIN

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