LHX8

Across TCGA cell cohorts, LHX8 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX8-associated genes across cancer lineages are OR10G7, LCE1F, and OOSP4B. Each is linked with LHX8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX8-to-partner and partner-to-LHX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G7 grouped by LHX8-low versus LHX8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX8→partner) and Y-score (partner→LHX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10G7 →	+0.016	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	LCE1F →	+0.151	+5.662	<.001	.002	3	1
SKIN	OOSP4B →	+0.075	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	RAX2 →	+0.091	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR10G7 by LHX8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →