LHX6

Across TCGA patient cohorts, LHX6 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX6-associated genes across cancer lineages are p21, eEF2, and EGFR_pY1068. Each is linked with LHX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX6-to-partner and partner-to-LHX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by LHX6-low versus LHX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX6→partner) and Y-score (partner→LHX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.151	+2.662	.036	<.001	3	3
COAD	eEF2 →	+0.449	+2.815	.005	.036	3	2
UCEC	EGFR_pY1068 →	-0.231	-2.169	.014	.003	3	2
UCEC	NF-kB-p65_pS536 →	-0.403	-2.459	.018	.018	3	2
UCEC	Bax →	+0.271	+1.594	.002	.042	3	2
UCEC	A-Raf_pS299 →	-0.090	-2.459	.045	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p21 by LHX6 expression — UCEC

Explore this box plot interactively →