LHX6

Across TCGA cell cohorts, LHX6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX6-associated genes across cancer lineages are RASGEF1C, P2RY12, and C1QB. Each is linked with LHX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX6-to-partner and partner-to-LHX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASGEF1C grouped by LHX6-low versus LHX6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX6→partner) and Y-score (partner→LHX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.216	+3.404	.006	.006	3	1
LARGE_INTESTINE	P2RY12 →	+0.088	+3.103	.009	.004	3	1
LARGE_INTESTINE	C1QB →	+0.087	+2.994	<.001	.006	3	1
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	1
CNS	MYF6 →	+0.050	+4.169	<.001	.008	3	1
CNS	FSHB →	+0.018	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

RASGEF1C by LHX6 expression — LARGE_INTESTINE

Explore this box plot interactively →