LHX5

Across TCGA pan-cancer cohorts, LHX5 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LHX5 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher LHX5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LHX5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, BLCA, and LIHC are the cancer types where LHX5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.261	0.798	.006	12	view →
BLCA	OS	Median	All	0.201	0.720	.005	6	view →
LIHC	OS	Median	All	0.164	0.688	.030	6	view →
UCEC	DFS	Median	All	1.000	0.635	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LHX5–CESC (OS)

Open the CESC breakdown →