LHX5

Across TCGA patient cohorts, LHX5 mutation is significantly associated with the RNA expression of many other genes, with 863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX5-associated genes across cancer lineages are RNA5SP215, FANCC, and UIMC1. Each is linked with LHX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX5-to-partner and partner-to-LHX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP215 grouped by LHX5-low versus LHX5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX5→partner) and Y-score (partner→LHX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP215 →	+0.202	+4.438	.003	.006	3	3
UCEC	FANCC →	+0.453	+3.491	.003	.002	3	2
UCEC	UIMC1 →	+0.385	+2.756	.006	.002	3	2
UCEC	MCM5 →	+0.575	+3.191	.004	.009	3	2
UCEC	GNPDA1 →	+0.422	+3.716	.004	<.001	3	2
UCEC	TTL →	+0.403	+3.223	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

RNA5SP215 by LHX5 expression — LUSC

Explore this box plot interactively →