LHX5

Across TCGA patient cohorts, LHX5 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX5-associated genes across cancer lineages are HSP70, JNK2, and Ku80. Each is linked with LHX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX5-to-partner and partner-to-LHX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by LHX5-low versus LHX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX5→partner) and Y-score (partner→LHX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.417	-2.999	.017	.035	3	1
UCEC	JNK2 →	+0.344	+3.594	<.001	.001	3	1
UCEC	Ku80 →	+0.288	+3.013	.005	.018	3	1
UCEC	MEK1 →	+0.412	+2.115	.009	.019	3	1
UCEC	MSH2 →	-0.283	-2.973	.004	.035	3	1
UCEC	p62 Lck ligand →	+0.298	+3.179	.036	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

HSP70 by LHX5 expression — UCEC

Explore this box plot interactively →