LHX5

Across TCGA cell cohorts, LHX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 895 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible LHX5-associated GO terms across cancer lineages are Response to unfolded protein, Regulation of intrinsic apoptotic signaling pathway, and Regulation of apoptotic signaling pathway. Each is linked with LHX5 in more than 8 cancer types. Because this analysis shows association rather than direction, both LHX5-to-partner and partner-to-LHX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to unfolded protein grouped by LHX5-low versus LHX5-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX5→partner) and Y-score (partner→LHX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to unfolded protein →	+0.104	+0.322	<.001	.009	3	9
BREAST	Regulation of intrinsic apoptotic signaling pathway →	+0.060	+0.276	.001	.007	3	6
BREAST	Regulation of apoptotic signaling pathway →	+0.063	+0.279	<.001	.006	3	5
PANCREAS	Calcium ion export across plasma membrane →	-0.931	-0.338	<.001	.007	3	5
OESOPHAGUS	BMP signaling pathway →	-0.058	-0.789	.003	.001	3	5
URINARY_TRACT	Regulation of iron ion import across plasma membrane →	+0.185	+0.462	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 895 associations by consensus.

Response to unfolded protein by LHX5 expression — URINARY_TRACT

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