LHX5

Across TCGA cell cohorts, LHX5 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LHX5-associated genes across cancer lineages are OR6B1, GP9, and BAAT. Each is linked with LHX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX5-to-partner and partner-to-LHX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B1 grouped by LHX5-low versus LHX5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX5→partner) and Y-score (partner→LHX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR6B1 →	+0.096	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	GP9 →	+0.022	+3.947	<.001	.004	3	1
LARGE_INTESTINE	BAAT →	+0.449	+3.465	<.001	.002	3	1
LARGE_INTESTINE	MSTN →	+0.225	+3.215	<.001	.009	3	1
LARGE_INTESTINE	VAX1 →	+0.561	+2.782	.001	.007	3	1
LARGE_INTESTINE	SYN2 →	+0.686	+3.243	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

OR6B1 by LHX5 expression — LUNG_SCLC

Explore this box plot interactively →