LHX4

Across TCGA patient cohorts, LHX4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,050 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LHX4-associated genes across cancer lineages are SNX14, FANCF, and TCTE3. Each is linked with LHX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX4-to-partner and partner-to-LHX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHX4 versus SNX14 in GBM, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX4→partner) and Y-score (partner→LHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNX14 →	-0.523	-0.399	.001	.002	3	2
GBM	FANCF →	-0.501	-0.423	.001	.001	3	2
GBM	TCTE3 →	-0.533	-0.344	.004	.004	3	2
LUAD	KPNA5 →	-0.411	-0.489	<.001	<.001	3	2
GBM	LYRM2 →	-0.303	-0.299	.004	<.001	3	2
HNSC	RNF11P2 →	-0.733	-0.773	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,050 associations by consensus.

LHX4 vs SNX14 — GBM

Explore this scatter interactively →