LHX4

Across TCGA patient cohorts, LHX4 mutation is significantly associated with the RNA expression of many other genes, with 1,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX4-associated genes across cancer lineages are GOT1, MRPL39, and LETM1. Each is linked with LHX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both LHX4-to-partner and partner-to-LHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by LHX4-low versus LHX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX4→partner) and Y-score (partner→LHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GOT1 →	+0.400	+2.801	.003	<.001	3	4
UCEC	MRPL39 →	+0.354	+2.346	.008	.003	3	3
UCEC	LETM1 →	+0.391	+2.290	.003	.001	3	3
SKCM	NIPA1 →	+0.818	+3.469	.001	.002	3	3
UCEC	HSPA9 →	+0.461	+2.616	.001	.005	3	3
UCEC	ETFA →	+0.646	+3.906	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,215 associations by consensus.

GOT1 by LHX4 expression — UCEC

Explore this box plot interactively →