LHX4

Across TCGA patient cohorts, LHX4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX4-associated genes across cancer lineages are ASNS, PDCD4, and PCNA. Each is linked with LHX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LHX4-to-partner and partner-to-LHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LHX4-low versus LHX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX4→partner) and Y-score (partner→LHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.347	+2.321	.020	.033	3	3
UCEC	PDCD4 →	-0.429	-2.999	.027	.035	3	2
UCEC	PCNA →	+0.226	+2.321	.011	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.904	+3.720	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.280	+3.029	.012	.018	3	2
STAD	SF2 →	+0.488	+2.828	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ASNS by LHX4 expression — UCEC

Explore this box plot interactively →