LHX4

Across TCGA cell cohorts, LHX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,186 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LHX4-associated GO terms across cancer lineages are Positive regulation of monoatomic ion transmembrane transport, Viral translational termination-reinitiation, and Regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with LHX4 in more than 14 cancer types. Because this analysis shows association rather than direction, both LHX4-to-partner and partner-to-LHX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of monoatomic ion transmembrane transport grouped by LHX4-low versus LHX4-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX4→partner) and Y-score (partner→LHX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of monoatomic ion transmembrane transport →	-0.097	-0.539	.003	.005	3	15
SOFT_TISSUE	Viral translational termination-reinitiation →	+0.101	+1.210	<.001	<.001	3	15
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.202	+1.026	<.001	<.001	3	14
LARGE_INTESTINE	Spliceosomal complex assembly →	+0.090	+0.838	<.001	<.001	3	14
STOMACH	Subtelomeric heterochromatin formation →	+0.113	+0.669	<.001	.002	3	14
BONE	Negative regulation of translational initiation →	+0.141	+1.039	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,186 associations by consensus.

Positive regulation of monoatomic ion transmembrane transport by LHX4 expression — PANCREAS

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