LHX2

Across TCGA patient cohorts, LHX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,764 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LHX2-associated proteins across cancer lineages are UHRF1, CBX2, and DIPK2A. Each is linked with LHX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LHX2-to-partner and partner-to-LHX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHX2 versus UHRF1 in GBM, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX2→partner) and Y-score (partner→LHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UHRF1 →	+0.635	+1.164	<.001	<.001	3	4
HNSC	CBX2 →	+0.636	+0.579	.001	.003	3	4
BRCA	DIPK2A →	+0.599	+0.441	<.001	<.001	3	4
GBM	GMPR2 →	-0.278	-0.945	<.001	<.001	3	4
GBM	VAT1 →	-0.340	-1.093	<.001	<.001	3	3
BRCA	PSMG2 →	+0.299	+0.366	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,764 associations by consensus.

LHX2 vs UHRF1 — GBM

Explore this scatter interactively →