LHX2

Across TCGA patient cohorts, LHX2 protein abundance is significantly associated with the RNA expression of many other genes, with 7,813 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LHX2-associated genes across cancer lineages are EP300, ZMYND8, and ADNP. Each is linked with LHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX2-to-partner and partner-to-LHX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LHX2 versus EP300 in GBM, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX2→partner) and Y-score (partner→LHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EP300 →	+0.746	+0.888	.001	.002	3	1
GBM	ZMYND8 →	+0.477	+0.654	.002	.003	3	1
GBM	ADNP →	+0.501	+0.609	.003	.008	3	1
GBM	PLCB4 →	+1.855	+0.985	.001	.008	3	1
GBM	MAPRE1 →	+0.336	+0.668	.006	.003	3	1
GBM	MLNR →	+0.440	+0.674	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,813 associations by consensus.

LHX2 vs EP300 — GBM

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