LHX2

Across TCGA patient cohorts, LHX2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LHX2-associated genes across cancer lineages are Ku80, PCNA, and ATM. Each is linked with LHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LHX2-to-partner and partner-to-LHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by LHX2-low versus LHX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX2→partner) and Y-score (partner→LHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.276	+2.335	.004	.003	3	2
UCEC	PCNA →	+0.221	+1.807	.013	.027	3	2
UCEC	ATM →	-0.419	-1.807	.025	.027	3	2
UCEC	4E-BP1 →	+0.238	+3.351	.033	.005	3	2
UCEC	A-Raf_pS299 →	-0.116	-2.459	.018	.018	3	1
UCEC	ERK2 →	+0.164	+2.321	.039	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Ku80 by LHX2 expression — UCEC

Explore this box plot interactively →