LHX2

Across TCGA cell cohorts, LHX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,199 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LHX2-associated GO terms across cancer lineages are Heterochromatin formation, Regulation of chromosome organization, and Epigenetic regulation of gene expression. Each is linked with LHX2 in more than 11 cancer types. Because this analysis shows association rather than direction, both LHX2-to-partner and partner-to-LHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by LHX2-low versus LHX2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LHX2→partner) and Y-score (partner→LHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Heterochromatin formation →	+0.059	+1.382	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome organization →	+0.052	+1.052	.005	<.001	3	12
BLOOD_Lymphoma	Epigenetic regulation of gene expression →	+0.059	+1.037	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Protein-DNA complex organization →	+0.066	+1.581	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	U2-type prespliceosome assembly →	+0.117	+1.727	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.045	+1.224	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,199 associations by consensus.

Heterochromatin formation by LHX2 expression — OVARY

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